Sentence examples for serious limitation when from inspiring English sources

However, observational studies suffer from methodological drawbacks, which prevent meaningful conclusions and represent a serious limitation when data from different reports are pooled for systematic reviews and meta-analyses.

Our simulation data indicates that having a single reference can, in some cases, be a serious limitation when using this technique.

This can be a serious limitation when performing computing intensive tasks such as hierarchical clustering, permutation-based statistical testing, or normalization of exon arrays.

However, current output only techniques have serious limitations when applied to some practical cases.

However, being empirical fitting equations, they have serious limitations when their asymptotic behaviour is considered, or when the empirical constants are not directly calibrated with experiments.

Whereas techniques commonly used for nanoparticle characterization, such as light scattering techniques, show serious limitations when applied to complex samples, other well-established techniques, like electron microscopy and atomic spectrometry, can provide useful information in most cases.

Classical formulation available in the literature typically assumes a number of unknowns that increases with the number of layers and this sets serious limitations when trying to solve practical problems.

Even if they have serious limitations when applied to 'true' nanosized objects, methods initially developed for 'bigger' particles (usually for submicron particles) are usually applied to study 'pure' ENPs, but there is a serious dearth of applications in the case of 'real' matrices.

But microarray data have serious limitations when it comes to biological inference.

Our investigation demonstrates that habitat surrogates can be very useful for certain aspects of monitoring programs, but that serious limitations prevail when trying to monitor changes over time, or if information on species-specific responses is required.

But their earlier models have had serious limitations: Even when they catalyze the same chemical reactions as the real enzymes, they rarely do so in the same way.