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The term "serious limitation" is correct and usable in written English
You can use it to discuss a serious restriction or impediment, for example: One of the serious limitations of this research is the lack of access to primary sources.
Exact(59)
Another serious limitation of T2 and T2* relaxometry methods is the limited access to the technique [15, 21, 22, 23].
This is a pretty serious limitation.
There is another serious limitation, for all birders.
That Avandia actually worsens patients' heart status "denotes a serious limitation of anticipated therapeutic benefit," the report concluded.
"This doesn't make the study wrong or inaccurate, but it's a serious limitation which they didn't mention".
In the U.S., such a ban would be opposed by conservatives and liberals alike as a serious limitation on religious freedom and freedom of expression.
Is this a serious limitation of GEM?
Another serious limitation is the type of science Iris can intelligently parse.
This is a serious limitation and can lead to erroneous results.
The shortage of long distance electric power transmission capacity is another serious limitation.
This leads to a serious limitation for investigation of PEDOT PSS-NH3 interactions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com