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It can be infused rapidly over less than 1 hour without serious infusion reactions, and so far no major toxicities have emerged.
"F.D.A. needs a serious infusion of resources and strong leadership dedicated to reforming the agency," said Representative Henry A. Waxman, Democrat of California, who is chairman of the House oversight committee.
Mr. Wilson's controlled vision, marked by his typically lush suffusions of light, could use a serious infusion of messy disorder, something to break through its cloying prettiness and give a fuller sense of who Ms. Hanayagi is, and why she is important.
But in the absence of those conditions, it is hard to imagine the Americans and others giving the green light for a serious infusion of the kind of quality weapons - such as MANPAD anti-aircraft missiles and much more - that the rebels need if they are to stand a chance of tilting the balance back in their favour.
The incidence of serious infusion reactions across 3 clinical studies (n = 234 patients) was 8.1%.
Serious infusion reactions occurred in two patients (one each antibody positive and negative).
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Of the three patients who had a serious infusion-related reaction (IRR), none were HAHA positive.
Serious infusion-related reactions occurred in 5% (pegloticase biweekly) and 8% (pegloticase monthly) of patients.
Serious bleeding during infusion: ENHANCE, 3.7%; PROWESS DrotAA, 2.4%; and PBO, 1.3%.
Observed serious bleeding rates (infusion as well as 28-day) in the stratified groups were similar to all-event rates.
In the 28-day study period (which included the 96-hour infusion), serious bleeds occurred in 3.9% of Canadian patients (6.9% of non-Canadian patients).
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