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To be surprised, we find that at very early age liver already exhibits serious gene expression alternations involving in bile metabolism dysfunction, inflammation, increased apoptosis and decreased proliferation, which greatly contribute to diabetes development.
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Therefore, serious changes in gene expression would occur under this condition.
However, these methods have serious drawbacks because gene expression can be affected by several factors, including the developmental stage of the plants.
Especially, this problem should be serious when analyzing a diverse gene expression data set like a multiple tissue data set.
Devising software specialized in searching for regulatory elements in noncoding regions of the genome is a serious challenge, but advances in gene expression analysis technologies allow detection using computational TFBS methods and development of databases containing position weight matrices (PWMs), such as JASPAR [ 9] and TRANSFAC [ 10].
Alterations in brain-derived neurotrophic factor (BDNF) gene expression contribute to serious pathologies such as depression, epilepsy, cancer, Alzheimer's, Huntington and Parkinson's disease.
Microbial RNA degrades rapidly, and for GIT colonic tissue and fecal samples, the time delay until RNA can be extracted may result in a serious distortion of active organisms and gene expression patterns from in situ.
Otherwise, genes with serious codon bias and significant correlation with gene expression will be low in ENc values and show points far lower than the standard curve.
They consider this phenomenon as a serious handicap to the inference on correlations in gene expression data analysis.
However, the genetic heterogeneity of the human population is a serious obstacle to the correct interpretation of data in gene expression studies.
Loss of the stable gene expression that maintains cellular phenotype is extremely serious for the organism and can, amongst other things, lead to the formation of cancers.
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CEO of Professional Science Editing for Scientists @ prosciediting.com