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This is a serious drawback, which results in higher detection limits than in high-performance liquid chromatography (HPLC), especially if injection of a small sample volume is required.
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However, this model has some serious drawbacks, which include increased delay and additional memory for the log LUT handling.
But the AK-47 has a serious drawback: glint, which gave Mr Malalo an advantage in firefights.
Membrane bioreactor technology exists for a couple of decades, but has not yet overwhelmed the market due to some serious drawbacks of which operational cost due to fouling is the major contributor.
The drugs that are currently available to treat this condition pose serious drawbacks [ 5], which justifies the search for new hepatoprotective agents.
However, most of the recent investigations into the design and optimization of biomass supply chains have focused on an economic point of view, sidelining other dimensions of sustainability, which represents a serious drawback for this kind of work.
This alternative modelling technique has a black box character, which is a serious drawback for application in medical practice.
Methods using ion exchange chromatography or direct amperometric detection cause a rather quick fouling of the electrode, which is a serious drawback of direct oxidation.
Muscovite mica is well-known for its excellent thermal and electrical isolation, which represents a serious drawback for UPS analysis due to charging effects.
Although there have been some studies on population genetics of codon usage variation in Drosophila (Akashi 1994, 1995; Begun 2001; Kern and Begun 2005; Galtier et al. 2006; Begun et al. 2007; Haddrill and Charlesworth 2008; Zeng and Charlesworth 2010), the data sets have been small in terms of numbers of sites and/or alleles, which is a serious drawback for investigating weak selection.
Dealiasing radial velocities is a time-consuming process, which can be a serious drawback in an operational context.
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