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Then he said, chuckling, that it was "unlikely" he would back McCain "unless he has a serious change, a lobotomy or something like that".
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To make a serious change to a complex system, you usually have to be big.If true, this argument has profound implications for policymakers (though Mr Mandel does not spell them out).
For the military here, a serious change in Egypt means a strategic shift in planning.
However, Mr. Kan failed to persuade the public that his new antinuclear stance represented a serious change of heart by a leader who before March supported building new nuclear plants.
Despite recent reforms, Burma remains one of south-east Asia's poorest countries, and serious change will require a huge investment of time and resources.
The round was led by Spring Ventures with the participation of Serious Change, Jim Sandler, Steve Wolf, Tom Chi, and a group of angels from the "Toniic" investor network.
"If there is a serious change of policy by Iran, and a serious change of engagement over the next few months - yes it's possible to resolve this quickly".
I've enjoyed their headphones before, but the S5i is their first rugged set to my knowledge, though with headphones and in-ears in particular, rugged is really more a style than a serious change in hardware.
Alice Nah said these reforms do not amount to a serious change in policy, and do not warrant an upgrade in Malaysia's status.
For China to make any concessions now is as much a reflection of new economic conditions as a serious change of heart.
Ultimately, the Indian government has to pull off a very tough trick, making serious changes at a time when things seem to be going very well.
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