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"While we face serious challenges as a result of 9/11 and the national economic downturn, we're confident we can manage them," said Carole E. Stone, the governor's budget director.
The World Food Program, a United Nations agency and the world's largest food distribution organization, "has probably never had as many serious challenges as we have today," said James T. Morris, the executive director of the agency.
Once off-track, youth face serious challenges as they attempt to re-engage and become a participating, productive member of society.
Still, going to the playground with Sacha posed some serious challenges, as his wheelchair would often get stuck in the layer of sand around the play structures, and Sacha was unable to play with most of the equipment.
A truce between the main gangs of El Salvador, brokered over two years ago and supported by the Organization of American States OASS), is now facing serious challenges as the murder rate increases in one of the world's most violent countries.
The pharmaceutical industry is facing serious challenges as the drug discovery process for neurodegenerative diseases is becoming extremely expensive, riskier, and critically inefficient.
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"I think his reputation was under serious challenge as early as the 1890's.
As WikiLeaks controversies have ratcheted up since then, simply keeping the site operational has become a serious challenge, as have further e-mail discussions.
The chaos that ISIS is bringing to the region and the larger world, presents a serious challenge as well as an opportunity for Israelis and Palestinians.
Even with such collaborative efforts, incorporating environmental risk factor data into models of predisposition is likely to be a serious challenge as, although ethnicity can be defined through genotype, environmental background is harder to standardise.
People familiar with the N.C.A.A. say the moves appear to be motivated by mitigating legal threats as the N.C.A.A. faces a serious challenge as a result of a lawsuit filed by the former U.C.L.A. basketball player Ed O'Bannon.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com