Sentence examples for serious challenge given from inspiring English sources

Realistically, that pretty much seals it for English: it is hard to imagine any serious challenge given Key's full-throated endorsement.

Development of effective therapies for intracellular eukaryotic pathogens is a serious challenge, given the protected location of these pathogens and the similarity of their biology to that of the host.

Serious challenges lay ahead given the complex nature of cytotoxic metabolism with multiple players working together to influence drug effectiveness and/or toxicity.

Today the CNS drug development poses serious challenges for developers given the low probability of success and the disproportionately high investment costs.

Update Updates Keep the operating system and other software updated regularly via the Web a serious challenge for dial-up users given the massive downloads often required.

Whilst we look set to finish in the top four, I can't really see us mounting a serious challenge for the title, especially given our current form, can you?

I do think that E. E. Cummings gives Graves a serious challenge, though I know that many sound people dismiss Cummings's love poetry outright, as self-congratulatory and goopy.

In fact, Sunnyvale, Calif.-based AMD is beginning to give Intel a serious challenge in retail PC market share.

Sony and Nintendo pretty much have it locked up now, but Sega Enterprises could come out of a distant third place to give them a serious challenge.

This certainly gives rise to a serious challenge when confronted with everyday intuition.

We're all better off if they pick somebody who will at least give the Democratic nominee a serious challenge.