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No serious bleeding complications were recorded in connection with the insertions of central venous catheters.
The concomitant administration of heparin seems not to result in an increase in serious bleeding complications.
Serious bleeding complications after treatment with Fab occurred in our study, consistent with past reports.
Estimates of serious bleeding complications in these latter trials ranged between 6.0% [ 9] and 12.8% [ 10] for placebo treated patients.
Five serious bleeding complications were reported when using enoxaparin, but anti-Xa activity in these patients was the same as in those without bleeding (p = 0.77) [ 36].
Overdosage, as manifested by increased anti factor Xa activity (> 2 IE/ml) may lead to serious bleeding complications and increased mortality rates [ 4].
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1 2 Gastrointestinal haemorrhage is the most common serious bleeding complication associated with antithrombotic treatment.
Consistent with its antithrombotic and profibrinolytic properties, the administration of drotrecogin alfa (activated), as compared with placebo, was associated with an increase in the percentage of patients experiencing a serious bleeding complication (3.5% versus 2.0%; P = 0.06) over 28 days in the phase 3 study [ 4].
This desired target INR depends on the indication: a target INR ≤ 2.1 is the aim in case of a minor (urgent) surgery or serious overdosing of anticoagulant with bleeding complications, while a target INR ≤ 1.5 is the aim for severe bleeding complications with hemodynamic instability or cerebral bleeding, or if acute surgical intervention is needed [3, 4].
Published cases of serious late bleeding complications have often arisen in the setting of very laterally or caudally placed tracheostomy tubes, which eventually eroded into vascular structures [ 5].
However, thrombolysis has adverse effects, the most serious being bleeding complications that can cause symptomatic intracranial haemorrhage (SICH) within 24 36 hours following treatment, which usually leads to severe disability or death [ 16, 17], although overall mortality with thrombolysis is not increased and risk of long-term disability significantly reduced [ 18, 19].
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