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At the time, use of the CD4 blood count to detect serious abnormalities of the immune system was limited to a few research centers.
In the same study, serious abnormalities of the heart rhythm occurred in 11 % of the cooled children and 9 % of the others.
In the 6 newborns left in which differences were noted in scores between the two sequential scans, there were no serious abnormalities of the first scans that normalized in the second week.
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The main anticipated serious adverse event (SAE) for riluzole was serious abnormality of liver function tests defined as ALT >5× the upper limit of normal.
At discharge from hospital, 68% (n=705) of survivors had bronchopulmonary dysplasia (receiving supplemental oxygen at 36 weeks postmenstrual age), 13% (n=135) had evidence of serious abnormality on cerebral ultrasonography, and 16% (n=166) had laser treatment for retinopathy of prematurity.
These included severe abnormalities of the head arteries, the suprarenal gland and derivatives of the vitelline veins, all of which constituted serious lesions that could impair embryo viability.
A rise in the serum potassium to perhaps 6.2 milliequivalents per litre, as can occur when large numbers of cells are severely injured or die and potassium ions are released, could cause serious abnormalities in the performance of the heart by disturbing the regularity of the nervous impulses that maintain the heart's rhythm.
Hemodynamic monitoring revealed serious abnormalities in 23% of patients; all in this group who underwent surgery despite a warning died [ 10].
The potential detection of more serious abnormalities, together with voice contact and GPS location offer a real degree of improved safety compared to a patient exercising with no supervision or monitoring.
About 5percentt of babies born in the United States each year have some type of birth defect, and about half of those have serious abnormalities.
Brain scans of Nasa astronauts who have returned to Earth after more than a month in space have revealed potentially serious abnormalities that could jeopardise the future of long-term space missions.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com