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Although earlier invasive serial studies have documented the progression of atherosclerotic burden, most were focused on high-risk patients only.
In patients with cone-rod dystrophy consequent upon RPGR or RIMS1 mutations, serial studies have recently demonstrated ring expansion [ 26], suggesting an expanding front of macular photoreceptor dysfunction.
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There is good evidence that serial SEP studies have provided useful information about the functional recovery of impaired areas [ 16, 17].
Single-cell and serial transplantation studies have revealed significant heterogeneity in both the mature cell production and self-renewal durability of individual HSCs (Beerman et al., 2010; Dykstra et al., 2007; Goodell et al., 1996; Morita et al., 2010).
However, some serial cross-sectional studies have found greater reductions in HIV prevalence among the more educated groups, especially in cohorts of young adults [ 7, 8].
Serial cross-section studies have suggested that separate populations of ER+/EGFR- and ER-/EGFR+ cancer cells exist in tumours deemed by immunocytochemical assay (ICA) to be positive for both.
Other related studies have examined serial effects on simple visual stimuli (Marshall et al., 2004).
Several studies have reported serial pipelines to predict miRNAs from Caenorhabditis elegans, Drosophila, Arabidopsis and human [ 6- 9].
Recently many long-term prospective studies have involved serial collection and storage of blood or tissue specimens.
As dengue infections are very dynamic, more recent studies have investigated serial changes in cytokine patterns in patients with acute dengue infection.
Studies have used serial sectioning with or without immunohistochemical stains for the detection of micrometastatic foci and, as described, these methods have been shown to have a definite impact on detection rates.
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