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Enzyme pairs that are used in exactly the same reactions, or which are coupled in an obligate serial pathway, have a flux correlation of 1.
Metabolite sharing can miss associations between non-consecutive enzymes in a serial pathway, and shortest-path algorithms are sensitive to high-degree metabolites such as water and ATP that create connections between enzymes with little functional similarity.
There was no evidence of a serial pathway between neurocognition and multiple mediators and violence, and only social cognition and violence proneness operated in parallel as significant mediators accounting for 46%% of the variance in violent incidents.
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The mechanism of the reaction follows mainly parallel rather than the expected serial pathways.
However, in evaluating the significance of these more complex (serial) pathways it is clear that though significant, they are modest.
The study focuses primarily on the steady-state analytical solutions of the tetrachloroethene (PCE) serial degradation pathway and secondly on the analytical solutions of the parallel degradation pathway.
Moreover, the logic is serial: only one pathway can be followed by a single patient.
In this pathway, a serial process leads to caspase-9 activation.
Caspase-3 cleavage derived huntingtin fragments undergo further proteolysis by calpains, generating smaller products and suggesting a proteolytic pathway of serial processing events [ 20].
Since the IHC data suggested dysregulation of the p53 pathway following serial tumor passaging, we investigated if a gene set consisting of direct p53 effectors ('PID_P53DOWNSTREAMPATHWAY' from the MsigDB database) is differentially expressed between luminal A and claudin-low murine tumors.
Excel spreadsheet programs were created to facilitate prompt application of the steady-state analytical solutions, for both the serial and parallel degradation pathways.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com