We investigated how developmental time windows for axon outgrowth affect network connectivity by analyzing non-overlapping (serial growth) and maximally overlapping (parallel growth) time windows for axon growth.
Overlapping serial fragments of BRCA2, with the exception of the extreme C terminus, which could not be expressed in vitro, were constructed by PCR and introduced into pGEX2T to express GST-fusion proteins.
Here, we explore the extreme cases of axon formation during early development, either starting at the same time for all neurons (parallel, i.e., maximally overlapped time windows) or occurring for each neuron separately one neuron after another (serial, i.e., no overlaps in time windows).
Additionally, we tested partially overlapping time windows with a small partial overlap and a large partial overlap; serial growth is the extreme case of small overlap, i.e., zero overlap and parallel growth is the opposite end where time windows of axon growth are maximally overlapped (see details in Online material A10 and Figures A10 A12).
uses a heteroscedasticity and autocorrelation (HAC) robust variance-covariance matrix towards a fixed length of serial correlation of up to twice the overlap (here ± 3 months or 90 days/7 days per week ≈ 13 weeks)5.
Concurrent partnerships are those in which an individual has two or more partnerships which overlap in time, as opposed to "serial monogamy" where one partnership ends before another one starts.
Short assessment periods should be used in studies of patients whose FHS varies over time and in studies involving serial assessments to ensure that there is no overlap in assessment times.
In the serial TI paradigm subjects learn a sequence of overlapping premise pairs (i.e., A > B > C > D > E) and inference (B > D) rests on knowledge of stimulus order.
Stacked images from adjacent serial sections were superimposed to highlight the differential distribution or overlap of retrogradely labeled neurons and anterogradely labeled boutons.
Everything we saw -- the interlocking, overlapping events involving aliens, Nazi sadists, nuns, a serial killer, mental patients, etc. -- amounted to a series of explorations.
