However, the lack of correlation with measures of disease activity precludes serial measurement of these biomarkers as a strategy to monitor early responses to therapy with synthetic DMARDs.
Efficacy was assessed with serial measurement of muscle sympathetic nerve activity (MSNA) and clinical measures of quality of life and functional capacity.
From the clinical point of view, the values provided by the serial measurement are most informative.
Serial measurement of CRP can be used as risk assessment and prognostic marker.
Serial measurement is useful to distinguish nonspecific elevation of a tumor marker.
Reliable serial measurement of cognitive processes in rehabilitation: the Cognitive Log.
Serial measurement of CMV viral load provides valuable information and opportunity for intervention.
For that reason serial measurement of lithium levels is inevitable (Timmer and Sands 1999; Okusa and Crystal 1994).
However, some organizations recommend serial measurement of the CA15-3 level based on its reported usefulness for the postoperative surveillance of breast cancer patients by small studies [1].
In a previous trial in dyspneic patients (BACH trial) we could show that serial measurement of MR-proADM proves useful for risk assessment and patient monitoring.
Serial measurement of the biomarkers showed that for both bio-ADM and lactate, a normalization of concentration was associated with a decrease in mortality risk, while a continuing high concentration or increasing concentrations were associated with a high mortality risk.
