Gating-charge-carrying Rs were observed to make serial interactions with E183 in S1 and E226 in S2, in the outer water crevice.
By activating endothelia over only one of the regions, the device reproduces serial interactions of tumor cells with endothelia of differing metastasis-supporting potential as occur physiologically.
A few individuals engaged in serial interactions, temporarily settling in an area with several fishing vessels, amongst which they commuted, possibly obtaining food and pausing between foraging bouts.
Considering serial interactions as separate sampling units, the total number of all interactions (single and serial) is reduced to 30, with a mean duration 5.4±7.1 hours, and a median of 2.1 hours (range 9 minutes to 25 hours).
We have described a compact, easily-fabricated microfluidic system to model serial interactions of circulating cancer cells with a vascular endothelium at defined sites stimulated extravascularly from the basal side by chemokines.
Sometimes birds remained in the general vicinity of a ship (or group of ships) after the end of an interaction, only to approach the same vessel(s) again, minutes or (up to 8) hours later; hereafter, these are referred to as serial interactions.
Initially, T cells make transient contacts (stochastic scanning) with antigen-presenting DCs, and their behavior then progresses from serial interactions to formation of dynamic T cell clusters, T cell dissociation and swarming, leading ultimately to several rounds of T cell proliferation.
In budding yeast, the intersection of checkpoint mechanisms at strategic points along the cell cycle continuum is believed to foster coupled serial interactions between certain transcription factors and regulate the pace of transcriptional change through key cell cycle transitions (see reviews [73], [74]).
This provides new insights into the improvements of the sparsification of the concatenation-rule Λ∗ in the presence of cross serial interactions.
