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Thus, serial injections of sustained-delivery polymer gel loaded with sirolimus can provide high localized concentrations at target vascular tissues and thus may be useful for the prevention and treatment of vascular proliferative disorders such as hemodialysis graft stenosis.
- Promote myoblast proliferation and differentiation in vitro (Huard et al. 2002) - Hypertrophic effect of IGF-1 (Barton-Davis et al. 1999) - Serial injections of IGF-1 imuscle muscle healing in vivo (Menetrey et al. 2000).
The "acute-on-chronic" or microsurge effect refers to agonistic testosterone stimulation occurring in response to serial injections of GnRH agonist depots.
Three 60 s start-up injections of Nanodisc SPR buffer were followed by serial injections of nanodiscs for 90 120 s.
These included two different DOX treatments: an acute in vitro administration to primary isolated adult rat ventricular cardiomyocytes (ARVCMs) and an in vivo model of DOX-induced HF (Supplementary Figures 2 and 3), created by serial injections of the drug as previously described.
Heat of binding was measured from 11 serial injections of Ca2+ (3.5 µl of 7 mM Ca2+ for C2A and 15 mM Ca2+ for C2B; higher [Ca2+] was needed to saturate C2B) into a sample cell containing 1.5 mg/ml (100 μM) protein at 25°C.
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In this report, the beads were injected at a volume of 4.6 or 23 nL by serial injection of the unit volumes (2.3 nL or 4.6 nL).
Serial injections (2 μL) of varying concentrations of drug were injected, and the area under the curve (AUC) was calculated for peaks at 0.8 and 1.6 minutes for ciprofloxacin and diclofenac sodium, respectively.
Studies examining the toxic effects of serial injections have yet to be conducted.
A pattern was applied to the skin to precisely mark injections points, thus allowing reproducibility of serial injections at each time-point.
None of our patients reported these side effects, even though many of them had serial injections.
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