Furthermore, it eschews (implausible) Markovian assumptions about the serial independence of random fluctuations.
Although in several collaborative studies, we have shown that each approach has utility (Cristofanilli et al, 2004; Hussain et al, 2006; de Bono et al, 2008), important limitations have been identified: many tumours do not produce tumour-associated antigens, or there will be discordance between fluctuations in serial levels and response to treatment (Cristofanilli et al, 2004).
We then calculated the rate of loss of heterozygosity (LOH) at ACT2 from the number of resistant cells and the number of cell divisions following the initial inoculation (determined from viable cell counts obtained by serial dilution) using the fluctuation test method of Luria and Delbrück [ 29].
explores how spectral subtraction and dynamic-range compression gain modifications affect temporal envelope fluctuations in parallel and serial system configurations.
Detection of the cycle is dependent on repeated, serial, near-daily measurements to define cyclical fluctuations in the inflammatory markers.
To our knowledge, only a single study of acute LBP has employed frequent serial assessments permitting a characterization of pain fluctuations during the early course of acute LBP[ 8].
The number of release sites determined by fluctuation analysis (∼600) and postsynaptic current analysis (∼380) in our study is similar to the number of AZs reported previously using serial EM images (∼500) (57), current analysis (∼380) (42) or fluctuation analysis (∼500) (39).
While serial independence can be checked for, the nature of neuronal fluctuations may deserve more attention in the future.
At this time BPb measurements are still the most reliable indicator of recent Pb exposure, although serial BPb measurements may offer a better assessment of temporal fluctuations in Pb absorption.
Furthermore, it is now well-known that environmental fluctuations have different forms depending on the level of serial correlation between years, and that these correlations to a large extent affect population dynamics [7] [9].
