The serial BCR engagements and antigen extractions should provide additional B cell activation signals and saturate class II MHC molecules with peptide fragments, respectively.
The net effects of the seeming imbalance between pro-injurious and counter-regulatory (dampening) functions could conceivably result in promotion of more injurious responses with serial (chronic) antigen engagements (including intrapulmonary antigens [13]) by T-lymphocyte populations that have increased proportions of CD4+CD28null cells.
Although increased incidence of ARIAs and suggestive evidence that there may be slight reductions in amyloid loads based on serial amyloid scans support target engagement in the brain, the consequences of such engagement are poorly understood [ 54].
The "gossip" is a soap opera role that author Christine Geraghty has described as "crucial to the audience's engagement with a serial and provides both a source of information and a means of speculation for the viewer".
Alternatively, each engagement of pMHC with TCR (serial triggering; Valitutti et al., 1995), perhaps with some minimum engagement time (kinetic proof reading; McKeithan, 1995; Rabinowitz et al., 1996), might define the threshold for TCR triggering.
No, I did not break off the engagement (having been a serial fiancée for some time, I really had to go ahead and get married or no one would have taken me seriously ever again).
Limitations of this study were mitigated by use of serial interviewing and rapport development through prolonged engagement with participants.
One supervisor, explaining his engagement in the initiative, stated that: My accountant said GPs are serial altruists However, altruism alone will not sustain the engagement of clinicians in student teaching and learning.
8 P.M. (Fox) BONES At the end of Season 8, the serial killer Christopher Pelant (Andrew Leeds) forced Special Agent Booth David Boreanazz) to call off his engagement to Brennan Emily Deschanell, above, with Mr. Boreanaz), but not tell her why.
It was Kosovo more than any other engagement of the past 50 years that prepared an American military-political consensus in favor of serial wars against transnational enemies of whatever sort.
