Sentence examples for serial differentiation from inspiring English sources

With such a serial differentiation pattern, self-renewing cell populations are much more susceptible to somatic mutation, but these cells are rare and slow growing.

Leishmania amastigotes are ingested by sand flies in a blood meal and undergo serial differentiation before they are injected, as metacyclic promastigotes, into their subsequent mammalian host.

They harbour self-renewal, shown by in-vitro indefinite expansion and in-vivo serial transplantation experiments and differentiation capacity, as would be expected from a stem cell.

The present study is the first to examine intracellular Ca2+ signaling in hESC-CMs resulting from our recently reported guided differentiation protocol (involving serial activin A and BMP-4 under serum-free, monolayer culture conditions).

During keratinocytes differentiation, whether through serial subculture until senescence or exposure to high Ca++ level, there was a progressive loss of endogenous GRHL2 protein level in time-dependent manner.

Limiting dilution competitive transplantation analysis demonstrated a two- to fourfold increase in HSC number after short ex vivo PGE2 exposure, without creating an impact on multilineage hematopoietic differentiation or decreasing serial transplantation and self-renewal potential.

The complexity and diversity of arthropod body segments, tetrapod limbs, vertebrate teeth, and nymphalid butterfly wing color patterns all result from the evolutionary differentiation of homologous serial repeats [ 23- 26].

By designing clonogenic assays to measure stem cell differentiation in vitro and serial transplantation assays to study stem cell repopulating ability in vivo, Till and McCulloch defined the hallmark characteristics of stem cells.

Additionally, no differentiation was obtained with serial dilution and single cell plating in a 24- multi-well dish where single cell plating did pose a survival challenge (unpublished data).

In addition, the half-life of 99mTc is relatively long (6.02 h) compared to most nuclear imaging radioisotopes, which facilitates serial imaging that may improve the differentiation of tumor from inflammation.

This confirms the concept that cells with lower levels of Pax7 have a higher propensity for differentiation leading to their loss in serial transplantation.