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This study investigates serial alterations in blood lipids in the 1,2-dimethylhydrazine (DMH) rat model of colon cancer.
The serial alterations of the paw withdrawal threshold (mean ± SEM) throughout the whole experiment for each group are shown in Figure 2B.
The serial alterations of the percentage of edema (mean ± standard error of the mean, or SEM) throughout the whole experiment for each group are shown in Figure 2A.
Serial alterations in protein C levels appear to correlate with disease severity in patients with severe sepsis, and it may be possible to tailor severe sepsis therapy with the use of this biomarker.
Serial alterations in protein C also appear to correlate with disease severity as measured by the development of organ failure and the evolution of those organ failures [ 11, 12].
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HNC displays serial dysplastic alterations before acquiring invasive characteristics.
Thus, serial genetic alterations avoid the increasing metabolic cost of antibiotic resistance genes, multiple polar effects on nearby genes, and use native promoters to maintain the level of transcription of pathway genes.
The aim is to manufacture the components as far as possible in serial production without alterations.
Noticeably, human tumour cell lines in culture accumulate genetic alterations during serial passaging that dramatically alter their biological behaviour [ 40].
Unfortunately, the use of cell lines for translational research has disadvantages because genetic and phenotypic alterations from serial passaging have resulted in expression profiles that are different from the original patient tumors.
Chronic inflammation resulting from liver fluke infection, hepatitis and other inflammatory bowel diseases is a major contributing factor to cholangiocarcinogenesis, likely through accumulation of serial genetic and epigenetic alterations resulting in aberration of oncogenes and tumour suppressors.
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