Sentence examples for sequestration strength from inspiring English sources

Further analysis suggested that strength of the negative feedback loop is a function of the sequestration strength.

We show that PSEQ also adds on to the output duration and readjustment of sequestration strength can facilitate the system to control the output memory further.

Such gain in robustness in K2_QSS models (as compared to their K2 counterparts) owes its origin in the phosphatase sequestration strength in K2_QSS.

It could be noted that control of the strength of the implicit feedback loop through adjustment of the sequestration strength is a robust property of a MAPK cascade such as M4, as both M4K1 and M4K2 (simulated with different sets of parameters) exhibited similar relation between sequestration strength and the strength of the implicit negative feedback loop.

Simulation of the models with variation of their sequestration strength revealed that feedback loop from Phos2 to MKKK-P could be abolished in both M4K1 and M4K2 by increasing the phosphatase sequestration strengths.

As calculated from the K2 models, the sequestration strength (Kseq) used in K2_QSS is 0.06nM, and the Km values for dephosphorylation are 4 orders of magnitude higher than the Kseq values.

In M4K2 the sequestration strengths were changed by changing rate at which unphosphorylated MKKK, MKK and MK are bound to their phosphatases.

But output memory of K2_QSS systems in PSEQ conditions could be easily achieved in similar orders of magnitude to the K2 systems only by readjusting the sequestration strengths, while keeping rest of the model parameters constant (Data not shown).

As both the models showed changes in the similar direction in MKKK-P amplitude in the PSEQ condition (feedback effect is either reduced or abolished), we next compared the effect of variable sequestration strengths in both M4K1 and M4K2.

For the analysis, we varied the sequestration strengths in both the models, while keeping all the other model parameters constant and plotted the steady state MKKK-P amplitude differences for Phos2 = 5 nM (low Phos2 concentration) and Phos2 = 1000 nM (High Phos2 concentration).

It was observed that as a function of increasing strengths of sequestration, the differences in MKKK-P amplitudes for the high and low value of Phos2 decreases, and after certain strength of sequestration (~30 nM), changes in the Phos2 concentration couldn't affect the MKKK-P amplitude.