Overexpression of transport systems required for enhanced sequestration, Tissue-specific expression of proteins, High metal chelator concentrations.
Another alternative for heavy metal detoxication is the intracellular sequestration in specific vacuoles producing solid granules [ 47].
For many tumors, their selective survival dependence reflects tonic Bim sequestration by specific Bcl2 pro-survival proteins.
However, a clear mechanism definitively linking sequestration of specific RNA-binding proteins to disease pathogenesis (as is the case for myotonic dystrophy) is currently lacking.
P. chabaudi AS provides a good model to investigate the influence of the host response on the sequestration and specific organ pathology, which is applicable to human malaria.
Second, both sense and antisense repeat transcripts accumulate in nuclear RNA foci and may cause the sequestration of specific RNA-binding proteins, which potentially impairs the physiological function of those proteins [ 15, 26, 43].
Moreover, the high molecular weight of most mAb constitutes a limitation since sequestration by specific cells might result in diminution of available, free mAb able to bind to the target of interest.
Furthermore, studies determine the sequestration potential in specific regions or specific land-cover types (e.g. [13 15]).
Furthermore, studies determine the sequestration potential in specific regions or specific land-cover types (e.g. [ 13- 15]).
HBsAg is believed to be important for immune evasion of HBV through sequestration of HBsAg-specific neutralizing antibody particles and possibly by inducing HBV-specific T-cells tolerance through repetitive stimulation by high-dose antigen [ 4].
There are cultural-specific "sequestration rituals", she notes, around menstruating women.
