In the case of rodent infections with malaria parasites of which there are three known species, one of the features of P. berghei-, P. yoelii-, and P. chabaudi-infected erythrocytes is their ability to sequestrate in various organs of the body [ 30– 33]; however, the sequestration patterns differ from that of P. falciparum-infected erythrocytes [ 34, 35].
As an alternative, model-based approaches can be specified to be dynamic by incorporating future forest conditions and global change scenarios to determine their implications on C stocks and sequestration patterns.
Although aridity was not found to influence the global distribution of coarse root biomass [8], what role might precipitation and/or its interaction with temperature and other climate variables play in determining future C sequestration patterns and stocks?
To test for differences in sequestration patterns between various mouse strains a transgenic P. berghei line (pbGFP-LUCsch) was used that expresses a GFP-luciferase fusion protein under the control of the schizont-specific promoter from the ama1 gene of P. berghei [27].
This will improve our understanding of the impact of physiological and environmental factors on CO2 efflux and sequestration patterns over the region.
Finally, as a means of refining NGHGIs, climate-adjusted models depicting belowground C stocks should be adopted to incorporate the impacts of future global change and management scenarios on C sequestration patterns and stocks.
Although aridity was not found to influence the global distribution of coarse root biomass [ 8], what role might precipitation and/or its interaction with temperature and other climate variables play in determining future C sequestration patterns and stocks?
We therefore asked whether the adaptive immune response and inflammatory cytokines would affect P. chabaudi sequestration in vivo using mice lacking T and B cells (rag1−/−), the IFNγ receptor (ifnγr−/− mice), or IL-10 (il10−/−.) As the major differences in sequestration patterns were seen between days 5 and 9 p.i. in C57BL/6 mice, those time points were chosen for further analysis.
We do not know whether these regulatory mechanisms may be altered in CLDs, although it has been proposed that inactivation of IRP-2 (which is usually highly expressed in macrophages) by RNS may help to explain iron sequestration patterns of macrophages detected in tissues undergoing inflammation [ 125].
