Sentence examples for sequestration of substrate from inspiring English sources

Some regulatory RNAs can also bind specific protein as their target and modify protein activity or act by sequestration of substrate.

Additionally, this shielded conformation may protect against nonspecific oxidation of the active site cysteine, which would inactivate the enzyme, or, alternatively, prevent premature docking and sequestration of substrate proteins.

Sequestration of substrates by SQSTM1 involves the build-up of protein aggregates or inclusion bodies.

Due to the sequestration effect of substrate selective compounds, we have found that a necessary condition for this to take place in vivo is that [active p38] < [MK2].

These factors may include accessibility of the cleavage site, sequestration of the substrate through incorporation into larger complexes, conformational change after ligand binding, and subcellular localization.

Overexpression of PiCdc14 may misregulate proteins through excessive dephosphorylation or sequestration of its substrates.

Overexpression of GSTs in S. frugiperda may serve as a detoxification strategy by facilitating the sequestration of non-substrate ligands and thereby preventing their interference with essential cellular functions.

Our studies indicate that BAG3 might function in sequestration of chaperone substrates and the formation of inclusion bodies along with SQSTM1.

In contrast, microautophagy [ 5], the least studied form of autophagy, requires the sequestration of cytoplasmic substrates within lysosomal membranes per se that are then pinched off to deliver the cargo into the lysosomal lumen.

In the context of this model, the formation of aggregates and the exacerbated phenotype found in Δget1/Δget2 cells (Auld et al., 2006; Schuldiner et al., 2005) would be explained by disruption of the Get3 cycle, leading to sequestration of potential substrates.

Under these conditions one would expect the sequestration effect of substrate-selective compounds to take place.