Conversely, subsystems which are less frequently used but must react quickly tend to have stable mRNA but unstable proteins, consistent with low sequestration of static resources but a high demand on dynamic resources.
Fitness costs here may arise through nonproductive occupation of ribosomal capacity, which can be rate limiting for growth (Shachrai et al. 2010) or through sequestration of other translational resources (amino acids, tRNAs, etc)., which may prevent other proteins from being made in a timely fashion (Stoebel et al. 2008).
Current efforts at both the state and federal level are refining estimates of sequestration resources (e.g., DOE-NETL 2008; CEC 2007).
Lawyers in that office have now asked Judge Lewis Kaplan in Federal District Court to postpone the trial because the automatic federal budget cuts known as sequestration are leaving them short of resources and staff.
The static cost is due to the presence of a given amount E of total enzyme, which causes the sequestration of enzyme building blocks (resource R S, e.g. amino acids), leading to a nonlinear dependence on E (see Materials and Methods).
Ryan's Democratic counterpart on the Budget Committee, Rep. Chris Van Hollen (Md ., said Democrats still want to extend those benefits, but didn't want to lose the chance to soften the blow of sequestration and redirect resources to various infrastructure projects, education and medical research.
One key prediction of error models that focus on process costs is that such costs should strongly covary with the length of the erroneous product because residency time at the ribosome, the level of resource sequestration and the amount of energy wasted in protein synthesis and degradation should all increase with length.
What a misuse of resources!
With the exception of the Ebola funds, the budgets for the Centers for Disease Control and Prevention and the Food and Drug Administration have been relatively stagnant with sequestration squeezing resources even further.
