Exact(1)
Cells deficient in PINK1 were observed to have elevated levels of autophagic vacuoles and lysosomes in comparison to controls; also, stable PINK1 knockdown was able to induce autophagic mitochondrial sequestration, delivery of mitochondria to lysosomes and a decrease in the cellular levels of mitochondria (Dagda et al, 2009).
Similar(7)
As a new series of nano-material, MOPs have high outer and inner specific surface areas and are able to be applied in different areas such as catalysis, gas sequestration, drug delivery, molecule sensing, etc.
The anthropogenic system of the northern Andean highlands, including Páramos and high woodlands of the tropical cloud forests, is as important as the tropical glaciers in providing environmental services of capture, sequestration, and delivery of water toward the lowlands.
Similarly, CR1 transgenics showed 16-fold less hepatic transduction than WT mice, compatible with the role of CR1 sequestration in accelerating delivery to macrophages for degradation rather than allowing hepatocyte infection.
However, planting monocultures for carbon sequestration may preclude effective delivery of other ecosystem services.
The mechanism of CYP activation or inhibition by PGRMC1 is highly debatable; however, it is conceivable that it may involve drug delivery or sequestration, as a hydrophobic binding pocket has been identified on PGRMC1.
This progress of cargo, from sequestration in autophagosomes, to their delivery and degradation in lysosomes, is termed autophagy flux.
Polyscape currently includes algorithms to explore the impacts of land cover change on flood risk, habitat connectivity, erosion and associated sediment delivery to receptors, carbon sequestration and agricultural productivity.
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