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The study revealed that the zinc-resistant bacterium have series of mechanisms such as metal ion sequestration, active efflux of metal ions, bioprecipitation and changes in the cell wall of the bacterium cell to resist the toxicity of zinc.
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We postulate that the enhanced cytoplasmic localization of isoform 2 might lead to sequestration of active Rac1 in the cytoplasm, thus leading to lower levels of active Rac1 near plasma membrane and thus lower macropinocytosis.
Collectively, these observations suggest that E-cadherin-mediated sequestration of active β-catenin to the cell surface coincides with induction of PI3-K/AKT activity.
In Drosophila, cytoplasmic sequestration of active ERK is found in the developing eye and vein and marginal cells of the wing [6] [9].
Research and promotion of purposeful sequestration are active.
These mechanisms include extracellular precipitation, chelation and intracellular sequestration, and active extrusion from the cell or biochemical transformation (redox or methylation) [ 9].
As revealed by structural studies performed by Huber and colleagues [ 10, 11], the potentially catastrophic elimination of inappropriate substrates is prevented by sequestration of active sites within the hollow structure of the 20S proteasome.
This may imply that, there is higher sequestration of active principle(s) at certain level of polarity explaining the high but varied antibacterial activity demonstrated by fractions from solvents of different polarities.
This may be explained by sequestration of active TGF-β in lesional tissues such as the skin caused by upregulation of various TGF-β binding proteins, many of which are TGF-β inducible.
Given that as little as 10 110 molecules of siRISC per cell are sufficient for 50% knockdown of three different, relatively abundant mRNAs, but that the onset of RNAi after transfection is extremely fast, we reasoned that the sequestration of active Ago2 to membranes may be responsible for accelerating the silencing kinetics.
The presence of P-bodies in myo1Δ strains suggests that the process of mRNA sequestration is active, however, the three representative down regulated RP mRNAs, RPS8A, RPL3 and RPL7B were present at equivalent levels in Dcp2p-mCh-positive immunoprecipitated fractions from myo1Δ and wild type cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com