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CS chains have been proposed to function in two distinct ways: they can interact with a ligand either to present it to its receptor (positive function) or to sequester it from its receptor (negative function) [64].
RsmA is modulated by levels of the small RNA (sRNA) molecules rsmY and rsmZ, which bind to and sequester it from its targets.
In the case of prostate cancer, one mechanism could be through the ability to directly repress AR activity or sequester it from its nuclear targets.
CAF-1, in addition to chaperoning histone H3.1-H4, appearspears to chaperone HP1 [ 27], potentially collecting the parental HP1 that is released during DNA replication and acting to sequester it ready for its reincorporation onto the newly-replicated chromatin.
For all the clumsiness of the sequester, it is imposing new rigours.
The technology to remove co2 from the smokestacks and "sequester" it affordably is, he estimates, 10 to 15 years away.
The purpose of farming is to deprive other species of the land, and sequester it for our own use.
The ultimate goal is for the trees to retain the mercury, or, in the parlance of the scientists, "sequester" it.
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Similarly to PU.1, C/EBPα upregulates its own expression in murine cells, and it was previously suggested that RUNX1/ETO interferes with C/EBPα expression by sequestering it from its promoter and thereby suppressing autoactivation (Pabst et al., 2001a).
The increase in PPARγ levels serves as an additional β-catenin sink by sequestering it and activating its proteasomal degradation [ 41].
Efforts to achieve this goal have focussed mostly, thus far, on capturing CO2 and sequestering it at the source of its production.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com