Sentence examples for sequester active from inspiring English sources

The anti-TRAP protein (RtpA) can sequester active TRAP associated with TRP by protein-protein interactions.

Popular approaches include oligopeptides/peptidomimetics or G-quadruplex nucleic acids that target SH2 domains and disrupt STAT3 dimerization, or 'decoy' oligonucleotides that sequester active STAT3 and block the authentic STAT3-DNA interaction.

Bcl-2-like proteins in this model protect against apoptosis by sequestering active BH3-only proteins.

By sequestering active hormone, rising titers of carrier proteins such as CBG and SHBG in the maternal circulation may serve to protect the mother from adverse consequences of the rise in fetal production of steroids [ 83].

Since Bcl-2 sequesters active tBID and this way prevents cells from killing [ 19], it is probable that more BID is necessary in A549 than in PC3 cells to start apoptosis.

Rubin et al. [ 88] postulated that EGFR activation, followed by Spry2 phosphorylation and its association with c-Cbl, initiates a competitive process where c-Cbl promotes Spry2 polyubiquitination and degradation, and Spry2, conversely, sequesters active c-Cbl molecules and impedes receptor ubiquitination and degradation.

The inner loop was shown to: (a) sequester the active center from carboligase side reactions; (b) assist the interaction between the E1 and the E2 components, thereby affecting the overall reaction rate of the entire multienzyme complex; (c) control substrate access to the active center.

We conclude that the response of respiratory epithelial cells to asbestos includes oxidant-mediated mechanisms to sequester catalytically active iron associated with the fiber.

Alternatively, the interaction between TMEFF2 and PDGF-AA may either function to sequester the active PDGF ligand away from its receptor, or act as a carrier to concentrate or stabilize the PDGF ligand, depending on the local concentrations of these proteins in different cellular contexts.

In this way, trigger loop closing helps to frame and sequester the active site.

These enzymes are most likely β- d-glucosidases and xylanases, suggesting a new paradigm on the interaction of enzymes with lignin where strong hydrophobic (β- d-glucosidase) and electrostatic (xylanases) interactions with lignin can displace CBM lignin interactions, freeing up cellulases while sequestering still active β- d-glucosidase and xylanase activities.