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Patients in the 'both agents' category may have received the anti-HER2 agents either sequentially or concomitantly.
The pairs seem to be able to build several nests sequentially or concomitantly before actively using a nest.
Future studies in a larger cohort are needed to confirm if there is a different treatment effect when both the drugs are used sequentially or concomitantly.
Accordingly, we compared patients receiving lapatinib and trastuzumab (either sequentially or concomitantly) after completion of local therapy with individuals who only received trastuzumab plus/minus chemotherapy and a historical control group of HER2-positive subjects without any further targeted therapy.
Although the potential benefits of adding taxanes to anthracycline-based regimens remain controversial in terms of long-term outcomes (Bear et al, 2006), regimens combining anthracyclines with taxanes, either sequentially or concomitantly, are widely used.
Bartsch et al (2012) showed that among 80 patients with brain metastases from HER2-positive breast cancer, use of trastuzumab and lapatinib, either sequentially or concomitantly, with or without chemotherapy was significantly associated with a 72% reduction in risk of death compared with trastuzumab-based treatment alone (P=0.012).
Similar(54)
Is the overlapping phenotypical output the result of pathway modulations that are implemented sequentially (and thus likely in independent fashion) or concomitantly (and thus possibly in mutually interdependent fashion)?
Sequentially or synchronously, he-men consort polygynously.
How do you give the drugs, sequentially or in combination?
The three stages are carried out sequentially or in parallel.
In reality, people don't apply the strategies in the spectrum sequentially or even necessarily separately.
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