Moreover, we demonstrated that sequential samples can help track in the future clonal evolution in patients with MM.
Finally, MM_2326 demonstrates that sequential samples are consistent and show reproducible data when there is stable disease burden in the patient and the samples are obtained weeks apart.
Fifteen of 16 rejection episodes were marked by increases in IL-5 as revealed by analysis of sequential samples from individual patients.
Together, these four cases highlight the utility of cfDNA as a potential biomarker of disease response/progression in future studies via sequential samples during therapy, which is difficult to be performed using bone marrow biopsies.
We envision that ULP-WGS can be used in sequential samples during therapy to define response and progression but more importantly, those samples can be further analyzed for the specific resistant clones that emerge during therapeutic interventions in these patients.
A rotating carousel design allows for simultaneous sample collection, reaction, biomarker extraction and analysis of sequential samples.
In audio sampling mode, once a set of 32 sequential samples is acquired, the microcontoller performs a 32 point DCT on the audio signal to extract the frequency decomposition of the subject's voice.
Levels of anti-V3 Abs in buccal secretions were significantly higher in sequential samples derived from C4-447- C4-447-om C4-VH5-51-immunized animals.
The study analyzed many sequential samples of the blood of one African man from shortly after he was infected until about two years later, when he started to produce "broadly neutralizing antibodies".
To achieve this, HBV wild-type and dHBV levels were determined by Q-PCR in sera from 56 untreated chronic patients and 23 acute patients, in sequential samples from 4 treated-patients and from liver-humanized mice after HBV infection.
Furthermore, these methods, as relied on sequential samples analysis, are not suited for screening of large number of specimens.
