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These data demonstrate a sequential role for P2Y1R, p38 MAPK and TRPV1 in inflammation-induced thermal hyperalgesia; thus, peripheral P2Y1Rs activation modulates p38 MAPK signaling and TRPV1 expression, which ultimately leads to the induction of thermal hyperalgesia.
Collectively, these data establish the impact of classical monocytes on atheroprogression, identify a sequential role of CXCL1 in their mobilization and CCR1/CCR5 in their recruitment.
These data suggest a sequential role of ATG14 in autophagosome formation wherein it promotes the generation of LC3 lipidation-active vesicles from the ERGIC after which it may remain on these vesicles to provide one essential membrane for phagophore growth.
PAHX and SCD-1, another enzyme downregulated in NOD diabetic mice, play a sequential role in peroxisomal lipid processing, suggesting that disruptions in lipid homeostasis occur in diabetes and proteinuria.
IMPACT: Collectively, these data establish the impact of classical monocytes on atheroprogression, and identify a sequential role of CXCL1 in atherogenic mobilization of classical monocytes and CCR1/CCR5 in arterial recruitment of classical monocytes.
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From a detailed analysis of antennal mechanics, sequential roles for TRPN and TRPV in fly auditory transduction have been proposed [13].
The data also reveals a structural basis for the model of auditory chordotonal transduction in which the TRPN and TRPV channels play sequential roles in generating and amplifying the receptor potential, but have opposing roles in regulating active ciliary motility.
Based on these results, we propose a hypothesis that SlCLEs play important and sequential roles in the fruit ripening process.
In some cell types, Rab27a and Rab27b isoforms are expressed together, and recent data suggest that they may perform sequential roles in granule docking and exocytosis via engagement of different effectors (14, 20).
Last but not least, from the perspective of SDT, this study finds that psychological empowerment and core self-evaluations play a sequential mediating role in the relationship between authentic leadership and proactive behavior.
Our study reveals that neurons reenter migration several days after their initial positioning, thereby performing sequential developmental roles in olfactory cortex and neocortex.
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