Skin-wound healing is an orchestrated biological phenomena consisting of three sequential phases, inflammation, proliferation, and maturation.
The results suggest that independent and sequential stimulation in proliferation and osteo-differentiation stages could synergistically enhance the survivability, expansion, and osteogenesis of hMSCs, as compared to stimulating alone or simultaneously.
During the menstrual cycle, the mammary gland goes through sequential waves of proliferation and apoptosis.
The chondrocytes in growth plates continuously undergo a sequential process from proliferation to terminal hypertrophic differentiation.
Whereas changes in Ki-67 levels have been revealed by group comparisons, the strength of neoadjuvant studies is that it is possible to examine differences in individual cases and classify tumours according to sequential changes in proliferation.
For each round of pregnancy, the mammary gland undergoes sequential cycles of proliferation, differentiation and apoptosis, and alveolar ducts form and grow, differentiate to produce milk and, after lactation, cease, revert and regress to the pre-pregnancy state.
The eukaryotic cell cycle refers to the series of events comprising the sequential actions, during proliferation, of synthesis of DNA (S-phase) and cell division (M-phase) with intervening gap phases to allow cell growth (G1-phase, after M- but before S-phase) and to check the integrity of genomic material (G2-phase, after S- but before M-phase).
Normal acute wounds usually progress through an orderly sequential trajectory of hemostasis, proliferation, maturation, and remodeling [4].
We propose that this movement has been conserved in vertebrates and that it may have facilitated a new mode of cell proliferation (the sequential mode) for trunk elongation in an intense cell proliferation context.
