Sentence examples for sequential mutation from inspiring English sources

Results demonstrate that the sequential mutation method (SMM) and circular gene method (CGM) reduce the convergence time, and a substantial reduction is observed when these methods are combined with the Adaptive Group Mutation (AGM) method for the full adder implementation.

In conclusion, our genome-wide analyses have uncovered sequential mutation events, both known and novel, which delineate breast tumor progression.

Sequential mutation of the ND complex in ACC may result in a spiraling cycle of increased ROS production and dysfunction of the aerobic glycolytic mechanism with subsequently increased propensity for further mutation and dysfunction resulting in a competitive growth advantage for tumor cells.

Interestingly, APC may undergo sequential mutation and selection during progression [ 28].

To explore the significance of these, we undertook a systematic sequential mutation of the PI5P4Kβ and PI5P4Kγ putative G-loop regions to change them to the PI5P4Kα sequence.

Site-specific sequential mutation of four GTGT motifs within this 106 bp region resulted in pronounced loss of silencing in homozygotes at both sites tested, identifying an essential role for this motif in silencing at the vg PRE.

Eighty percent hereditary breast cancers are associated with inactivation of breast cancer-associated genes (BRCA) type 1 and 2 by sequential mutations.

It means that, even under different histories of sequential mutations, two or more individuals could exhibit the same genotype.

As human immunodeficiency virus type 1 (HIV-1) resistance to azidothymidine (AZT) requires selection of sequential mutations, it is a good system to study the impact of epistasis.

It is believed that multiple sequential mutations induce malignant transformation of a normal cell into the cancer founder cell, which then multiplies and evolves to become a clinically detectable tumor [4], [5].

However, the data are also consistent with 50% chronocoordinate events, putatively during strand replication or patch repair, and 50% independent sequential mutations without a requirement that both mutations be on the same molecule (8 of 8 allelic mutations observed when 4 of 8 are expected at random; p≤0.08).