However, previous reports on sequential long-term outcomes in similar patient populations have shown that the outcomes are relatively stable (Findlay et al. 1998, Amundsen et al. 2000, Atlas et al. 2000).
Although protective efficacy of individual vaccination in challenge experiments is evident, few studies have addressed the effect of sequential, long-term, vaccination strategies with 1 vaccine platform against multiple VHFs, including the VSV-based strategy.
In a canine model with left ventricular dysfunction produced by multiple sequential intracoronary microembolizations, long term treatment with metoprolol, a β1-selective blocker, has been reported to prevent the progression of LV systolic dysfunction and LV chamber dilatation [ 26].
Policies have had to adapt to changing circumstances, whilst focusing on sequential improvements aimed at achieving long term goals.
The policy message is clear: to secure sustained HRH change across a long period of time in a large country such as Brazil, policies have had to adapt to changing circumstances, whilst focusing on sequential improvements aimed at achieving long term goals.
Sequential therapy has the potential to change mRCC into a chronic disease that can be managed for long term through the administration of targeted agents in sequence.
