Sentence examples for sequential boundaries from inspiring English sources

In addition to determining sequential boundaries using an alpha spending function, the program can perform power computations, compute probabilities associated with a given set of boundaries, and generate confidence intervals.

Our aim was to compare sequential boundaries approach with the SSD when the allocation ratio (R) was not equal.

Sequential boundaries approach, the TT and DTT, permit repeated statistical analyses to be performed throughout the trial recruitment period in order to allow for early termination of a trial while maintaining a pre-specified α and β level.

Due to the lack of commutativity of the right fractional difference, the sequential boundary value problem is of interest.

Furthermore, combining the results of Goodrich [2] and Holm [10], there seem to be considerable possibilities for future work to address the sequential boundary value problems with left and right fractional difference operators, and such investigations might provide interesting future work.

Based on the O'Brien-Fleming approach group sequential boundary, the significance level for the primary end point was 0.025.

The log-rank test identical to the primary analysis will be performed at the scheduled interim analysis and compared to group sequential boundary based on the current information time.

Meta-analyses not reaching information size are analyzed with trial sequential monitoring boundaries analogous to interim monitoring boundaries in a single trial.

46 47 48 49 Meta-analyses not reaching the required information size are analysed with trial sequential monitoring boundaries analogous to interim monitoring boundaries in a single trial, requiring more stringent Z values to declare benefits or harms.

The cumulative z curve crosses neither the traditional boundary nor the trial sequential monitoring boundary but does cross the futility boundary, suggesting firm evidence for a lack of even an average 7.5% relative risk increase (upper confidence limit 11%) of myocardial infarction with angiotensin receptor blockers (see fig B1 in appendix 3 on bmj.com).

In order to calculate the required information size and the cumulative Z-curve's eventual breach of relevant trial sequential monitoring boundaries [17], [18], the trial sequential analysis was based on a type I error of 5%, a beta of 10% (power of 90%), the variance of all the trials (as no trial had low risk of bias), and a minimal relevant difference of 2 points on the HDRS.