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This ethics approved, prospective single cohort feasibility study was designed to evaluate the dosimetry and toxicity of CBRT using an intensity-modulated radiotherapy (IMRT) technique, compared with a standard sequential boost technique (SBT).
LNMs detected on 68Ga-PSMA PET/CT received a daily SIB of 2 Gy up to 56.0 Gy and a sequential boost up to 60.0 66.0 Gy.
red PTV including pelvic lymph nodes (50.4 Gy), blue simultaneous and sequential boost (66 Gy) for iliac (d) and presacral (c) LNM.
In patients with negative 68Ga-PSMA PET/CT, standard RT up to a total dose of 66 70 Gy using a simultaneously integrated boost (SIB) and sequential boost was administered to the prostate bed.
This is different in case of a sequential boost.
SIB does not cause higher dose to the surrounding OAR compared to sequential boost.
Similar(31)
A series of three studies published in this issue of Cell and a related paper in Immunity report new HIV structure-based design efforts focused on sequential boosting regimens with antigens of increasing maturation that point the way forward for an effective HIV vaccine strategy.
The adenoviral vectors were used to prime Balb/c mice followed by sequential boosting with chimpanzee type 63, and chimpanzee type 3 adenoviral vectors encoding SIVmac239 Gag and full length consensus Env.
Epitope-scaffolds were inoculated either in a homologous manner for each fusion protein (i.e., ES5 prime, followed by two ES5 boosts) or in a heterologous sequential manner (ES5, followed by ES1 and ES2 sequential boosts).
In this work, we also directly compared various heterologous two- or three-component vaccination regimens and found that the most potent at the vaccine doses used was a combination of the three employed vectors in a DNA priming followed by sequential boosts with rHAdV-5 and rMVA, or the DAM regimen.
For 10 patients 4 treatment plans were deployed, 1 with a sequential photon boost, and 3 with different SIB techniques: on a conventional linear accelerator, helical TomoTherapy, and static TomoDirect.
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