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These results suggest that the sequential administrations of PEGylated liposomes in well-spaced intervals might allow the distribution to different areas and enhance the total bulk accumulation within tumor tissue, resulting in better therapeutic efficacy of the encapsulated payload.
Our study shows that intravenous administration of furosemide, even at low doses, in patients with relatively normal renal function, induces an immediate subverting of both normal urinary excretion rate and concentration of main electrolytes, which commences very rapidly, and may have subsequent long-term effects as an additive result of sequential administrations.
We may hypothesize that the long-term effects of furosemide depend on its acute and immediate inhibition on Henle's loop, unveiling the activity of nephron proximal tubules, which, as an additive effect of sequential administrations, is responsible of the long-term effects observed.
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Simultaneous administration of interferons in the combination treatments was found to be superior to sequential administration.
Photodynamic therapy (PDT) involves the sequential administration of photosensitizing drugs and light to patients.
The sequential administration of docetaxel followed by AC showed a high antitumor activity and a good safety profile.
Results showed that PpIX-loaded Au@SNs-internalized tumor cells were effectively killed after the sequential administration of US and XR.
The current approach involves the sequential administration of an antibody, followed by administration of a small molecule radiotracer after 24 72 h. a TCO-modified antibody is administered first.
Both of these methods are characterized by sequential administration of dual tracers of 15O2 and C15O2 typically with a 3-min interval during a single PET scan.
One encouraging approach that has materialized from studies using such newer models is sequential administration of immunogens designed to bind progressively more mature bnAb predecessors.
Sequential administration of platinum-based doublet therapy and then a taxane may reduce the risk of drug resistance and, therefore, improve treatment outcome.
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