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Tumorigenesis is a multistep process that results from the sequential accumulation of mutations in key oncogene and tumour suppressor pathways.
While recombination can bring together multiple mutations within an organism, evolution in asexual populations depends on the sequential accumulation of mutations within a lineage.
In the context of asexual populations, the fitness valley crossing dynamics investigated so far require the sequential accumulation of mutations within individuals.
Vogelstein's research made it clear that tumours develop as a result of the sequential accumulation of mutations in proto-oncogenes, tumour-suppressor genes, and mismatch repair genes.
Failure process of composite laminate under quasi-static or fatigue loading involves sequential accumulation of intra- and interlaminar damage.
Folding of the Tetrahymena group I ribozyme includes sequential accumulation of two intermediates, termed Itrap and misfolded (M).
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This differential effect over male and female fertility could mean that the barrier has been strengthened over time by sequential accumulations of incompatibilities.
Shafer, O. T., Rosbash, M. & Truman, J. W. Sequential nuclear accumulation of the clock proteins period and timeless in the pacemaker neurons of Drosophila melanogaster.
However, if the abilities of the two workers are rather similar the employer optimally chooses sequential human capital accumulation with the underdog being the first mover.
First, as tumor development is believed to result from the sequential and progressive accumulation of genetic abnormalities, adult stem cells appear to be ideal initial targets for malignant transformation due to their long lifespans.
Population adaptation to strong selection can occur through the sequential or parallel accumulation of competing beneficial mutations.
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