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An interpretation of the relationship between activation energy, enthalpy and reaction sequencing is provided in Fig. 6d.

The diffusion of exome sequencing technology provided evidence for the role of rare coding variants in the aetiology of several complex diseases, and a cost effective alternative to exome sequencing is provided by the recent development of "exome" genotyping arrays, which were created to genotype rare coding variants identified by exome sequencing of thousands of individuals [28].

A detailed description of the genomic sequencing is provided in the methods.

A compatible set of 96 barcode sequences that have been used for multiplex sequencing is provided as supporting information (Table S1).

Detailed information for each of the PCR amplicons used for Sanger-based sequencing is provided in the supporting information (Table S1).

Detailed information of patient samples submitted for nucleotide sequencing is provided in the Table.

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DNA sequencing was provided by the Human Genome Center, Institute of Medical Sciences, University of Tokyo.

ASL-MRI sequencing was provided by GE.

Funding for 454® sequencing was provided by AIP Bioressources 2008 INRA.

Library construction and sequencing was provided by MWG (Germany).

Details of whole genome sequencing are provided elsewhere (18 ).

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