Your English writing platform
Free sign upExact(27)
Both the tiny MinIon and the larger GridIon look likely to be the first sequencers to use nanopore sequencing, in which a strand of DNA is read as it is pulled through a microscopic hole, sort of like a noodle being slurped through rounded lips.
An important approach used by many projects that sequenced large genomes involved hierarchical shotgun sequencing, in which segments of genomic DNA were cloned (copied) and arranged into ordered arrays.
An important application of this method is DNA sequencing in which the order of the four nucleotides (adenine, cytidine, guanine, and thymidine) in an oligonucleotide molecule must be determined.
Two of the three projects relied on newly developed technologies capable of deep-coverage sequencing, in which DNA segments were read rapidly multiple times to ensure that the determined order of bases was accurate.
Last month, Oxford Nanopore Technologies created an industry sensation when it introduced a machine that sequenced genes using an alternative approach called nanopore sequencing, in which a strand of DNA is read as it is pulled through a microscopic hole.
A major challenge for de novo sequencing, in which sequences are assembled for the very first time (such as with the HGP), is the production of individual DNA reads that are of sufficient length and quality to span common repetitive elements, which are a general property of complex genome sequences and a source of ambiguity for sequence assembly.
Similar(33)
The work is filled with sequences in which people creep laboriously.
The sequence in which revolutionaries storm the US embassy is brilliantly realised, though.
Presented as sequences in which these impressions are sorted out, the soliloquies have rarely sounded fresher.
These are the sequences that define life on Earth, the sequences in which we supposedly see ourselves most clearly.
The order in which the balls are removed from the train determines the sequence in which the notes are played.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com