Sentence examples for sequencing environment from inspiring English sources

The regular core production pipeline was not altered for this study, as the purpose is to assess sequence failure modes under ordinary conditions in a high-throughput sequencing environment.

We have observed that the proportions of reference to variant evidence can vary wildly between datasets, signifying that the relative alignment "affinity" of each of the alleles is highly sensitive to subtle changes in protocol (i.e. sample preparation, sequencing environment, revisions of the alignment software).

It therefore demonstrates the neighboring sequence environment is helpful for determination of cleavage site.

MacCarthy, T. et al. V-region mutation in vitro, in vivo, and in silico reveal the importance of the enzymatic properties of AID and the sequence environment.

Then, based on an estimated hydrophobic h-region a correcting function is proposed to improve the prediction result, in which the sequence environment is taken into account.

It is reported that the cleavage site has relationship with the neighboring sequence environment, i.e., hydrophobic core h-region, and the specific patterns in c-region.

However, in these models, sequence environment information is merely taken account of as model inputs and no detailed investigation into its effect on the prediction of cleavage site has been made.

In this study, the authors investigated the genomic architecture of PROS1 in order to understand the microscopic sequence environment leading to large intragenic copy number mutations in the gene.

Different types of human gene mutation may vary in size, from structural variants to single base-pair substitutions, but what they all have in common is that their nature, size and location are often determined either by specific characteristics of the local DNA sequence environment or by higher order features of the genomic architecture.

Consequently, a mirror image sequence environment has been established by mirror image algorithm.

With respect to the local sequence feature extraction, a sliding window method was used to capture the sequence environment [27], [42].