In contrast, the second mode is capable of creating, from mutually exclusive alternative sequences, a multitude of functionally distinct protein isoforms and thus might have a crucial role in the evolution of complex organisms [ 11].
In this era of large scale processing of Next Generation Sequencing, which includes RNA-Seq and Whole Exome Sequencing, and a multitude of other molecular profiling modalities, biomedical researchers are often left with a set of genes that show signs of biological significance.
Although variants using either CXCR4 or CCR5 are known to coexist in plasma, deep sequencing detected a multitude of distinct co-circulating V3 forms and highlighted the extraordinary diversity of V3 sequences available to the virus as it adapted to changing fitness environments.
The four main NGS platforms already allowed the de novo sequencing of a multitude of bacterial, archaeal, fungal, plant and animal genomes, and this development is spurred on by the rapid development of efficient sequence assembly software tools like "Velvet" [3].
The Human Genome Project has provided large-scale sequencing and a multitude of genetic databases, based on information from bacteria, plant, Drosophila, vertebrates and mammals [ 1- 5].
For epidemiologic and forensic purposes, whole-genome sequencing of a multitude of strains from well-documented outbreaks and the surrounding areas should be performed to clarify and possibly quantify the genetic changes that can finally confirm or rule out the route of transmission.
Two important advances include the International HapMap Project and the initiation of large-scale comparative genomics studies, both of which have been made possible by the availability of databases of genomic sequences of humans, as well as the availability of databases of genomic sequences of a multitude of other species.
High throughput genome sequencing has revealed a multitude of potential secondary metabolites biosynthetic pathways that remain cryptic.
After all, sequencing data will provide a multitude of clues, but few direct answers.
Nonetheless, if the same sequence takes place a multitude of times in different circumstances and the sequence takes place four out of five times -- tax cut, fiscal sector boom, bubble, crash, bank failures and recession or depression -- it makes a very good case for causality.
