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Promoters regulate gene expression through DNA recognition sequences, which interact with basic transcription initiation complexes and numerous transcription factors.
Stochastic competition models predict that the competing genes share common cis regulatory sequences, which interact with common transcription factors that are part of the regulatory complex.
They generally consist of a core DNA sequence (core promoter) along with other regulatory elements such as enhancers, silencers and other DNA sequences, which interact with DNA binding proteins (transcription factors) to drive transgene expression in various plant cells.
Transfection experiments using the pSVO-CAT vector and explanted lens epithelia from embryonic chickens demonstrated proximal (-88 to -60) and distal (-111 to -85) regulatory sequences which interact when the alpha A-crystallin promoter is activated in the lens cells.
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The KGD sequence, which interacts with epithelial integrins, is part of an exposed loop in domain II.
All opioid peptides share a common N-terminal YGGF signature sequence, which interacts with opioid receptors (Holtzman, 1974; Akil et al., 1998).
The penton base contains an Arg-Gly-Asp (RGD) sequence which interacts with host integrins to induce internalization of the virus [ 40].
Thirdly, the cytochrome P450-like TBP may, like HvPHO2, be protected by an unknown mimic sequence which interacts with miR827, inhibiting effective activity of the miRNA.
Beta-thymosins (Tβs) constitute a highly conserved family of actin-binding polypeptides [1], presenting a well conserved four-aminoacid motif, corresponding to the sequence LKKT, which interacts with actin, promoting or inhibiting actin assembly [2].
Most cancers, however, result from complex sequences of somatic mutations, which interact with each other to influence tumour evolution (Ashworth et al, 2011).
Peptide sequences, which very specifically interact with essential domains of target proteins, can be identified in yeast two hybrid screens [ 101].
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