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Methods for the in vitro generation and evolution of aptamers (RNA and DNA sequences which bind specific targets) are also now well established [4].
The Foxp3 promoter has been shown to contain consensus sequences which bind STAT5, resulting in high levels of STAT5 expression in Treg [36].
Similarly the promoter region of the rDNA genes was shown to be located in the same region with a few conserved repeat sequences, which bind to Topoisomerase I [21].
TFBSs are short DNA sequences which bind transcription factors that modulate the level of expression of their cognate gene(s) [ 3].
MARs, DNA sequences which bind to the nuclear matrix, may function as anchoring sites for higher order chromatin structures including loops (41, 82).
In contrast, mutation of the bipartite NLS-like sequences which bind MVP do not result in alterations in phosphatase function (21).
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The candidate sequence, 5' flanking sequence of the TH gene (-285 to -167 bp), was divided into five fragments namely A, B, C, D, and E. We determined the sequences, which bound the AhR-ARNT conplexposureposure to TCDD.
We selected 32 types of peptides as core sequences from the human GPI 558 amino acid sequence, which binds the binding motif, and synthesised 25 kinds of 20-mer peptides for screening, each containing the core sequence at its centre.
Origins share an essential core element called ACS (ARS Consensus Sequence), which binds the Origin Recognition Complex (ORC).
An example is the mRNA element SECIS (selenocysteine insertion sequence) which binds to the protein Se1B.
Moreover, by cross-linking to an H3K36 sequence (which binds to KDM4A C but not D/E, 69, Fig. 8), it was possible to demonstrate intra-subfamily selectivity (i.e. selectivity for KDM4A C over KDM4D/E).
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