Your English writing platform
Discover LudwigSuggestions(1)
Exact(1)
Since HLA-restricted cytotoxic T-cell responses select specific polymorphisms in HIV-1 sequences and HLA diversity is relatively static in human populations, we investigated the use of peptide epitopes based on sites of HLA-associated adaptation in HIV-1 sequences to stimulate and detect T-cell responses ex vivo.
Similar(59)
Thiolated CpG ODNs (5′-TCCATGACGTTCCTGACGTT-3′-SH), an effective sequence to stimulate immune responses of mice [31], could be successfully modified on Au NPs to form CpG-Au conjugations through Au S bond.
Mapping studies revealed that the peptide invariably induces strong proliferation of NZB CD4 T cells in vitro, and is the only sequence to stimulate responses by T cells from NZB mice prior to the onset of disease [8].
Cerebral ischemic reperfusion injury not only promotes the innate immune response of the immune system, but also activates TLR4-mediated signal transduction pathway to rapidly translocate NFκB from cytoplasm into nucleus, and combines with specific DNA sequence to stimulate downstream-associated factor (TNFα -induced inflammaTNFα -induced and inflammationresponseoptosis[ 27].
For example, mammalian genomes have more repetitive elements and segmental duplications than birds and these sequences are thought to stimulate chromosome rearrangements and copy number variation.
In our luciferase reporter-based assays, we found that one particular AP1 sequence is sufficient to stimulate reporter gene expression.
An inverted control sequence motif oligonucleotide failed to stimulate DC cultures to produce a cytokine response, showing that this effect was sequence specific.
We used ELISPOT assays to test the ability of 15-mer peptides containing sequences that fit the motif to stimulate IFN-γ release by PBMC from these three ECs.
These specific transcription factors usually bind upstream of the initiation site to specific recognition sequences of the regulated gene to stimulate or repress its transcription.
Earlier studies by Valcarcel and coworkers have shown that U2AF65, recognizing the 3′ss and/or U-rich sequences within introns, is able to stimulate interactions between U1 snRNP and the 5′ss [ 21].
Electroacupuncture (EA) apparatus can output a sequence of pulsed electrical current to stimulate the nerves and muscles of patients.
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com