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JUNB and JUND, components of transcription factor AP-1 and proto-oncogenes which interact with specific target DNA sequences to regulate gene expression, were identified as regulators of all genes of interest in our network.
JUN directly interacts with specific target DNA sequences to regulate gene expression.
Therefore, the characterization of OCR profiles could improve our understanding of how TFs are recognized in distinct genomic sequences to regulate target-gene transcription.
Glo regulates additional RNAs, however, and mammalian homologs bind G-tract sequences to regulate alternative splicing, suggesting that Glo also recognizes G-tract RNA.
Surface-modified temperature-responsive polymers are used as switching sequences to regulate interfacial phenomena and initiate unique biomedical and biotechnological applications.
Thin PIPAAm hydrogels on the biomaterials surfaces exhibit rapid and reversible phase transitions and act as switching sequences to regulate the interaction between the surfaces and biological materials by external temperature-induced changes.
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The phosporylated SMAD proteins then bind with SMAD4 to form the SMAD transcription factor complex which translocates into the nucleus and bind to the consensus DNA sequence to regulate the BMP target gene transcriptions [30], [32].
PPARs are ligand-activated nuclear receptors which form obligate heterodimers with RXR and interact with specific DNA sequence to regulate target gene expression.
These observations along with high intrinsic sequence preferences for nucleosomes at SDN-less promoters indicate that they need to use more energy in the form of ATP hydrolysis to override the underlying DNA sequence to regulate nucleosome mobility.
The activated AhR complex heterodimerizes with the aryl hydrocarbon nuclear translocator (ARNT), another bHLH-PAS family member, and binds dioxin response elements (DREs) containing the substitution intolerant 5'-GCGTG-3' core sequence to regulate changes in gene expression [ 4, 7].
MiRNA are a family of small non-coding RNA, approximately 21 to 25 nucleotides in length, 22, 23 that target mRNA at complementary sites in the 3′-UTR and coding domain sequence to regulate gene expression at a post-transcriptional level.
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