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From a systematic analysis of more than 50 mutational variants of AcP, Chiti et al. rationalised the propensities of some sequences to aggregate more rapidly than others, based simply on the physicochemical characteristics of the polypeptide chain: hydrophobicity, secondary structure propensity and charge [185].
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As an extreme example, more than half of the RNA in a pool of random RNA sequences was found to aggregate together through self-complementarity and precipitate out of solution under conditions favoring intramolecular interactions [ 38].
It has been conclusively argued that probe oligomers in close proximity containing poly-G motifs at the same sequence position are prone to aggregate into such parallel G-quadruplexes in the crowded conditions on the surface of high density microarrays [17], [45].
Far better than individual small cohorts of sequenced patients would be to aggregate cohorts and make their data widely available to qualified clinicians and researchers.
In addition, although target tracking per se is not considered in this paper, performance is evaluated both under the assumption that sequential location estimates are not aggregated as well as under the assumption that some sort of tracker is available to aggregate a sequence of estimates.
It has been shown that peptide fragments of PrP that contain the palindromic sequence show a high tendency to aggregate into β-sheet-rich amyloid fibrils [ 62] and are neurotoxic [ 63].
In this work, we have used tandem repeats of the prion like Q/N-rich region of TAR DNA-binding protein (TDP-43) fused to additional TDP-43 protein sequences to trigger aggregate formation in neuronal and non-neuronal cell lines.
There must be information to aggregate.
To aggregate stories is not fair use.
Different predictive methods have been developed to discover novel prions by either assessing the compositional bias of these stretches or estimating the propensity of protein sequences to form amyloid aggregates.
These rules can potentially be employed to design peptide sequences that aggregate into a preferred polymorphic form for nanotechnological purposes.
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