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We previously developed a series of peptide sequences that prevent closure of connexin43 (channelsannels, bind to cardiac Cx43, and prevent acidification-induced uncoupling of cardiac gap junctions.
In the case of converging genes, these share a terminator, that contains cis-acting sequences that prevent transcriptional collision between incoming RNA polymerases [ 4].
Genomic regions consisting of common or repeat sequences that prevent unique read alignment are said to have low mappability (Derrien et al. 2012; Graze et al. 2012; Stevenson et al. 2013).
Boundaries are defined as sequences that prevent regulatory elements from inappropriately affecting adjacent chromosomal regions; therefore, the blocking of bidirectional transcription by Pol III complexes can be viewed as insulating the divergent gene from the interfering effects of cryptic bidirectional transcription.
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Recently, a budding yeast centromere was modified by insertion of foreign sequences that prevented cohesin accumulation.
The lack of cross‐reactivity is likely to be the result of the divergent protein sequences that prevents antibody binding.
Unfortunately, telomeres were inadequately represented in the majority of fungal genome assemblies and, when they were present, the telomeric contigs were either too short to provide meaningful information, or they consisted of highly repetitive sequences that prevented unequivocal mapping of breaks (results not shown).
We assume that the human probes that are hybridized by the homologous baboon cDNA provide valid information, while the non-hybridized probe-sets can reflect either the absence of the transcript or differences in the baboon sequence that prevent hybridization.
Whenever a cut is repaired using the NHEJ pathway, the result is typically a drive-resistant allele with insertions or deletions in the target sequence that prevent it from being cut by the endonuclease.
Sequences that prevented correct assembly such as sequences from chimeric DNA were removed and the remaining contigs were re-aligned.
The first, which we will term a 'molecular null' is where the null allele contains a mutation in the DNA sequence that prevents the primer binding to it; this is the usual type of null encountered in population genetic studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com