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They can do this because the complete genome sequences of humans and many other species are available in databases.
One impetus came from the need to deal with the explosion of information based on the genomic sequences of humans and all major experimental organisms.
When the amino acid sequences of humans and rhesus monkeys are compared, they are found to be different at position 66 (isoleucine in humans, threonine in rhesus monkeys) but, identical at the other 103 positions.
In their quest to identify how the genome sequences of humans and primates vary, Song and Lowe discovered that the human CACNA1C gene contains a sequence that repeats as many as 1,000 times a 30-nucleotide sequence that is found only once in the chimpanzee genome.
Two important advances include the International HapMap Project and the initiation of large-scale comparative genomics studies, both of which have been made possible by the availability of databases of genomic sequences of humans, as well as the availability of databases of genomic sequences of a multitude of other species.
Genome sequences of humans, chimpanzees and orangutans are already published.
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The sequences of the primers are listed in Table 2. Table 2 Sequences of human primers.
Sjöblom, T. et al. The consensus coding sequences of human breast and colorectal cancers.
Sjoblom, T. et al. The consensus coding sequences of human breast and colorectal cancers.
The amino acid sequences of human aggrecan and rat aggrecan are about 75% identical.
Dutilh, B. E. et al. A highly abundant bacteriophage discovered in the unknown sequences of human faecal metagenomes.
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